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Engineering of Halogenases towards Synthetic Applications = Increasing the Thermostability and Investigations on a Marine Brominase Bmp5 /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Engineering of Halogenases towards Synthetic Applications/ by Hannah Minges.
Reminder of title:	Increasing the Thermostability and Investigations on a Marine Brominase Bmp5 /
Author:	Minges, Hannah.
Published:	Wiesbaden :Springer Fachmedien Wiesbaden : : 2017.,
Description:	xii, 116 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Enzymes - Biotechnology. -
Online resource:	http://dx.doi.org/10.1007/978-3-658-18410-0
ISBN:	9783658184100

Engineering of Halogenases towards Synthetic Applications = Increasing the Thermostability and Investigations on a Marine Brominase Bmp5 /
Minges, Hannah.

Engineering of Halogenases towards Synthetic ApplicationsIncreasing the Thermostability and Investigations on a Marine Brominase Bmp5 /[electronic resource] :by Hannah Minges. - Wiesbaden :Springer Fachmedien Wiesbaden :2017. - xii, 116 p. :ill., digital ;24 cm. - BestMasters. - BestMasters..

Halogenating Enzymes -- Identification of a Thermostable Thal Variant by Directed Evolution -- Establishment of the Brominase Bmp5 for Synthetic Application.

Hannah Minges focuses on the investigation of two different FAD-dependent halogenases in order to analyze and improve their applicability for chemoenzymatic approaches in chemistry. Owing to beneficial features, like high selectivity and benign reaction conditions, nature's toolkit for halogenation provides several advantages, whereas conventional chemical strategies require hazardous reagents and suffer from low selectivity. Therefore, enzymatic halogenation arises as promising alternative in the synthesis of valuable chemicals. One project focuses on the generation of a thermostable variant of the tryptophan halogenase Thal by means of directed evolution. The second project deals with the investigation of the marine halogenase Bmp5. This enzyme is of synthetic interest because it preferably introduces bromine into phenol compounds, whereas chlorination cannot take place. Contents Halogenating Enzymes Identification of a Thermostable Thal Variant by Directed Evolution Establishment of the Brominase Bmp5 for Synthetic Application Target Groups Lecturers, students and researchers in biological chemistry and chemistry The Author Hannah Minges, a Ph.D student at Bielefeld University, works on the optimization of tryptophan halogenases by means of directed evolution.

ISBN: 9783658184100

Standard No.: 10.1007/978-3-658-18410-0doiSubjects--Topical Terms:

582424
Enzymes
--Biotechnology.

LC Class. No.: TP248.65.E59 / M56 2017

Dewey Class. No.: 660.634

Engineering of Halogenases towards Synthetic Applications = Increasing the Thermostability and Investigations on a Marine Brominase Bmp5 /
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