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Superhydrophobic Titania Nanotube Arrays for Reducing Adhesion of Bacteria and Platelets.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Superhydrophobic Titania Nanotube Arrays for Reducing Adhesion of Bacteria and Platelets./
Author:	Bartlett, Kevin.
Description:	1 online resource (103 pages)
Notes:	Source: Masters Abstracts International, Volume: 57-01.
Contained By:	Masters Abstracts International57-01(E).
Subject:	Mechanical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9780355296792

Superhydrophobic Titania Nanotube Arrays for Reducing Adhesion of Bacteria and Platelets.
Bartlett, Kevin.

Superhydrophobic Titania Nanotube Arrays for Reducing Adhesion of Bacteria and Platelets. - 1 online resource (103 pages)

Source: Masters Abstracts International, Volume: 57-01.

Thesis (M.S.)

Includes bibliographical references

Hemocompatibility and bacterial infections cause challenges for medical devices. When any material is implanted into the body bacteria, blood, proteins and platelets will adsorb and attach to its surface. The platelet adsorption leads to thrombosis and clot formation on the surfaces, restricting blood flow and in some cases leading to inflammation and device failure. Bacteria adhesion leads to colony formation and eventually infection if left untreated. Infections can be treated with antibiotics, but growing antibiotic resistance among bacteria has spurred a search for methods that reduce infections without increasing resistance. Proposed methods have included diamond-like carbon surfaces, drug-eluting surfaces, and titania nanotube arrays. These methods have all shown some initial improved, but no approach has proven durable over long periods of time. Superhemophobic surfaces are a new approach to improving performance of medical devices, but the interactions of blood components and bacteria with these surfaces have not been well-documented. In this work, superhemophobic surfaces were developed by modifying the surface topography and surface chemistry of titanium. The surface topography was modified by creating titania nanotube arrays through a well-documented anodization and chemical etching technique. Superhemophobicity was induced by modifying the titania nanotube arrays with different silanes using chemical vapor deposition. The investigations of blood interactions with superhemophobic surfaces showed reduced protein adsorption. The bacteria adhesion studies showed reduced attachment for both gram-positive and gram-negative bacteria. The results indicate these surfaces have potential for enhancing material hemocompatibility and reducing the attachment of bacteria.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355296792Subjects--Topical Terms:

557493
Mechanical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

Superhydrophobic Titania Nanotube Arrays for Reducing Adhesion of Bacteria and Platelets.
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500 $a Source: Masters Abstracts International, Volume: 57-01.
500 $a Adviser: Ketul C. Popat.
502 $a Thesis (M.S.) $c Colorado State University $d 2017.
504 $a Includes bibliographical references
520 $a Hemocompatibility and bacterial infections cause challenges for medical devices. When any material is implanted into the body bacteria, blood, proteins and platelets will adsorb and attach to its surface. The platelet adsorption leads to thrombosis and clot formation on the surfaces, restricting blood flow and in some cases leading to inflammation and device failure. Bacteria adhesion leads to colony formation and eventually infection if left untreated. Infections can be treated with antibiotics, but growing antibiotic resistance among bacteria has spurred a search for methods that reduce infections without increasing resistance. Proposed methods have included diamond-like carbon surfaces, drug-eluting surfaces, and titania nanotube arrays. These methods have all shown some initial improved, but no approach has proven durable over long periods of time. Superhemophobic surfaces are a new approach to improving performance of medical devices, but the interactions of blood components and bacteria with these surfaces have not been well-documented. In this work, superhemophobic surfaces were developed by modifying the surface topography and surface chemistry of titanium. The surface topography was modified by creating titania nanotube arrays through a well-documented anodization and chemical etching technique. Superhemophobicity was induced by modifying the titania nanotube arrays with different silanes using chemical vapor deposition. The investigations of blood interactions with superhemophobic surfaces showed reduced protein adsorption. The bacteria adhesion studies showed reduced attachment for both gram-positive and gram-negative bacteria. The results indicate these surfaces have potential for enhancing material hemocompatibility and reducing the attachment of bacteria.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Mechanical engineering. $3 557493
650 4 $a Biomedical engineering. $3 588770
655 7 $a Electronic books. $2 local $3 554714
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710 2 $a Colorado State University. $b Mechanical Engineering. $3 1178987
773 0 $t Masters Abstracts International $g 57-01(E).
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