國立虎尾科技大學 |

A Modern Approach to Traditional Medicine : = Screening, Biofilm Formation, and Mechanism of Action in Candida albicans.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	A Modern Approach to Traditional Medicine :/
Reminder of title:	Screening, Biofilm Formation, and Mechanism of Action in Candida albicans.
Author:	Sutton, Caleb L.
Description:	1 online resource (108 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
Subject:	Molecular biology. -
Online resource:	click for full text (PQDT)
ISBN:	9781369760750

A Modern Approach to Traditional Medicine : = Screening, Biofilm Formation, and Mechanism of Action in Candida albicans.
Sutton, Caleb L.

A Modern Approach to Traditional Medicine :Screening, Biofilm Formation, and Mechanism of Action in Candida albicans. - 1 online resource (108 pages)

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

This item is not available from ProQuest Dissertations & Theses.

Middle Tennessee State University has created the Tennessee Center for Botanical Medicine Research by partnering with the Guangxi Medicinal Botanical Garden in Nanning, China and receives exclusive plant extracts used in that region for medicinal treatment. The Chinese, along with various other ancient cultures, have been using plants medicinally to treat everything from bacterial infections to terminal cancers for thousands of years. Until recently, modern approaches have not been used to understand the effectiveness and process by which traditional Chinese medicine (TCM) works. Along with the TCM extracts, aurones were utilized as well, a naturally occurring type of flavonoid in plants such as snapdragons and dahlias that lend the flowers a yellow pigment. Due to the antifungal activities of a group of related biosynthetic precursor compounds, flavonoids, it is reasonable to believe that aurones may also possess antifungal activity. Our organism of focus is Candida albicans, a polyphenic fungus that is known to cause opportunistic infections of the oral cavity and genitalia in humans in a variety of diseases under the collective term candidiasis, where this particular species is the most prevalent cause. We have used standardized screening methods to test the extracts and aurones against C. albicans where it was revealed that a great many of them exhibited antifungal activity with over 80% inhibition of growth. It was also discovered that a few of these extracts and compounds degrade C. albicans biofilm and prevent new growth. It is imperative to discover and develop new treatments for fungal infections due to the deleterious effects that current treatments such as amphotericin B have on the body and growing resistance to antifungals. The goal of this research was to find an alternative to the drugs currently used and understand how these alternatives work to eliminate infection. We have identified several compounds that can be used as alternative treatments and a probable target of one of the aurones in the threonine biosynthetic pathway.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369760750Subjects--Topical Terms:

583443
Molecular biology.
Index Terms--Genre/Form:

554714
Electronic books.

A Modern Approach to Traditional Medicine : = Screening, Biofilm Formation, and Mechanism of Action in Candida albicans.
LDR:03494ntm a2200361Ki 4500 001 910182
005 20180511093052.5
006 m o u
007 cr mn||||a|a||
008 190606s2017 xx obm 000 0 eng d
020 $a 9781369760750
035 $a (MiAaPQ)AAI10262615
035 $a (MiAaPQ)mtsu:10772
035 $a AAI10262615
040 $a MiAaPQ $b eng $c MiAaPQ
099 $a TUL $f hyy $c available through World Wide Web
100 1 $a Sutton, Caleb L. $3 1181309
245 1 2 $a A Modern Approach to Traditional Medicine : $b Screening, Biofilm Formation, and Mechanism of Action in Candida albicans.
264 0 $c 2017
300 $a 1 online resource (108 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
500 $a Adviser: Mary B. Farone.
502 $a Thesis (Ph.D.) $c Middle Tennessee State University $d 2017.
504 $a Includes bibliographical references
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Middle Tennessee State University has created the Tennessee Center for Botanical Medicine Research by partnering with the Guangxi Medicinal Botanical Garden in Nanning, China and receives exclusive plant extracts used in that region for medicinal treatment. The Chinese, along with various other ancient cultures, have been using plants medicinally to treat everything from bacterial infections to terminal cancers for thousands of years. Until recently, modern approaches have not been used to understand the effectiveness and process by which traditional Chinese medicine (TCM) works. Along with the TCM extracts, aurones were utilized as well, a naturally occurring type of flavonoid in plants such as snapdragons and dahlias that lend the flowers a yellow pigment. Due to the antifungal activities of a group of related biosynthetic precursor compounds, flavonoids, it is reasonable to believe that aurones may also possess antifungal activity. Our organism of focus is Candida albicans, a polyphenic fungus that is known to cause opportunistic infections of the oral cavity and genitalia in humans in a variety of diseases under the collective term candidiasis, where this particular species is the most prevalent cause. We have used standardized screening methods to test the extracts and aurones against C. albicans where it was revealed that a great many of them exhibited antifungal activity with over 80% inhibition of growth. It was also discovered that a few of these extracts and compounds degrade C. albicans biofilm and prevent new growth. It is imperative to discover and develop new treatments for fungal infections due to the deleterious effects that current treatments such as amphotericin B have on the body and growing resistance to antifungals. The goal of this research was to find an alternative to the drugs currently used and understand how these alternatives work to eliminate infection. We have identified several compounds that can be used as alternative treatments and a probable target of one of the aurones in the threonine biosynthetic pathway.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Molecular biology. $3 583443
650 4 $a Microbiology. $3 591510
655 7 $a Electronic books. $2 local $3 554714
690 $a 0307
690 $a 0410
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Middle Tennessee State University. $b Biology. $3 1180031
773 0 $t Dissertation Abstracts International $g 78-09B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10262615 $z click for full text (PQDT)