國立虎尾科技大學 |

Addressing Uncertainties in Health Utilities.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Addressing Uncertainties in Health Utilities./
Author:	Chan, Kelvin Kar-Wing.
Description:	1 online resource (160 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.
Contained By:	Dissertation Abstracts International79-03B(E).
Subject:	Biostatistics. -
Online resource:	click for full text (PQDT)
ISBN:	9780355479454

Addressing Uncertainties in Health Utilities.
Chan, Kelvin Kar-Wing.

Addressing Uncertainties in Health Utilities. - 1 online resource (160 pages)

Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

Uncertainties in health utilities have received little attention in the literature. Health utility is a preference-based quality of life measure. It is commonly used to calculate quality-adjusted life years and to conduct cost-utility analysis. Under-estimation of the uncertainty of health utilities will lead to under-estimation of the uncertainty of the results of any economic evaluation that requires the use of health utilities. This thesis focuses on addressing uncertainty in health utilities in three areas: (1) the underestimation of uncertainties of health utilities derived from mapping algorithms and the derivation of methods to address it, (2) the challenge with prediction error in multi-attribute utility instrument valuation studies with small sample size and an emphasis of the use of shrinkage estimators as a potential solution, and (3) the underestimation of uncertainties of health utilities derived from multi-attribute utility instruments with an emphasis of the use of multiple imputation as a potential solution. For each issue, theoretical statistical explanations are provided and then followed by the proposed methods to address those issues. Simulation methods are also used to explore the usefulness of the proposed methods.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355479454Subjects--Topical Terms:

783654
Biostatistics.
Index Terms--Genre/Form:

554714
Electronic books.

Addressing Uncertainties in Health Utilities.
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100 1 $a Chan, Kelvin Kar-Wing. $3 1183396
245 1 0 $a Addressing Uncertainties in Health Utilities.
264 0 $c 2017
300 $a 1 online resource (160 pages)
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500 $a Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.
500 $a Advisers: Eleanor M. Pullenayegum; Andrew R. Willan.
502 $a Thesis (Ph.D.) $c University of Toronto (Canada) $d 2017.
504 $a Includes bibliographical references
520 $a Uncertainties in health utilities have received little attention in the literature. Health utility is a preference-based quality of life measure. It is commonly used to calculate quality-adjusted life years and to conduct cost-utility analysis. Under-estimation of the uncertainty of health utilities will lead to under-estimation of the uncertainty of the results of any economic evaluation that requires the use of health utilities. This thesis focuses on addressing uncertainty in health utilities in three areas: (1) the underestimation of uncertainties of health utilities derived from mapping algorithms and the derivation of methods to address it, (2) the challenge with prediction error in multi-attribute utility instrument valuation studies with small sample size and an emphasis of the use of shrinkage estimators as a potential solution, and (3) the underestimation of uncertainties of health utilities derived from multi-attribute utility instruments with an emphasis of the use of multiple imputation as a potential solution. For each issue, theoretical statistical explanations are provided and then followed by the proposed methods to address those issues. Simulation methods are also used to explore the usefulness of the proposed methods.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biostatistics. $3 783654
650 4 $a Economic theory. $3 809881
655 7 $a Electronic books. $2 local $3 554714
690 $a 0308
690 $a 0511
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Toronto (Canada). $b Dalla Lana School of Public Health. $3 1183397
773 0 $t Dissertation Abstracts International $g 79-03B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10254097 $z click for full text (PQDT)