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Optogenetic dissection of cell types and circuits in mouse visual cortex.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Optogenetic dissection of cell types and circuits in mouse visual cortex./
Author:	Kyubwa, Espoir Magu.
Description:	1 online resource (127 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 77-12(E), Section: B.
Subject:	Biomedical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9781339863931

Optogenetic dissection of cell types and circuits in mouse visual cortex.
Kyubwa, Espoir Magu.

Optogenetic dissection of cell types and circuits in mouse visual cortex. - 1 online resource (127 pages)

Source: Dissertation Abstracts International, Volume: 77-12(E), Section: B.

Thesis (Ph.D.)--University of California, San Diego, 2016.

Includes bibliographical references

While many observations make it clear that cell types and specificity of connections matter, we still lack a mechanistic understanding of how cell types and their specific pattern of connectivity might contribute uniquely to cortical computations. To understand the contributions of cell types and circuits in mouse visual cortex we have taken advantage of multi-feature Boolean logical expression of light sensitive cationic channel (channelrhodopsin-ChR2) and whole cell dual patch recordings in living brain slices. Using these tools, we have identified unique electrophysiology and connectivity patterns of vasoactive intestinal peptide (VIP) expressing interneuron subtypes (Chapter 2). We have also introduced methods that will enable single cell resolution mapping of inhibitory inputs in the future (Chapter 3). Finally in Appendix A, we identified three layer 5 pyramidal cell types in mouse visual cortex based on intrinsic electrophysiology, visual responses, and long range connectivity. Better understanding of highly specific cell types and circuits in mouse models will help us better classify and treat psychiatric disorders in humans where inhibitory circuit dysfunctions have been implicated.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781339863931Subjects--Topical Terms:

588770
Biomedical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

Optogenetic dissection of cell types and circuits in mouse visual cortex.
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100 1 $a Kyubwa, Espoir Magu. $3 1186556
245 1 0 $a Optogenetic dissection of cell types and circuits in mouse visual cortex.
264 0 $c 2016
300 $a 1 online resource (127 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertation Abstracts International, Volume: 77-12(E), Section: B.
500 $a Advisers: Gert Cauwenberghs; Edward M. Callaway.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2016.
504 $a Includes bibliographical references
520 $a While many observations make it clear that cell types and specificity of connections matter, we still lack a mechanistic understanding of how cell types and their specific pattern of connectivity might contribute uniquely to cortical computations. To understand the contributions of cell types and circuits in mouse visual cortex we have taken advantage of multi-feature Boolean logical expression of light sensitive cationic channel (channelrhodopsin-ChR2) and whole cell dual patch recordings in living brain slices. Using these tools, we have identified unique electrophysiology and connectivity patterns of vasoactive intestinal peptide (VIP) expressing interneuron subtypes (Chapter 2). We have also introduced methods that will enable single cell resolution mapping of inhibitory inputs in the future (Chapter 3). Finally in Appendix A, we identified three layer 5 pyramidal cell types in mouse visual cortex based on intrinsic electrophysiology, visual responses, and long range connectivity. Better understanding of highly specific cell types and circuits in mouse models will help us better classify and treat psychiatric disorders in humans where inhibitory circuit dysfunctions have been implicated.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biomedical engineering. $3 588770
650 4 $a Neurosciences. $3 593561
655 7 $a Electronic books. $2 local $3 554714
690 $a 0541
690 $a 0317
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of California, San Diego. $b Bioengineering. $3 1180910
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10128381 $z click for full text (PQDT)