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Optogenetic-fMRI Investigations of A...

Liu, Jia.

Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies./
Author:	Liu, Jia.
Description:	1 online resource (145 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 78-06(E), Section: B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9781369430219

Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies.
Liu, Jia.

Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies. - 1 online resource (145 pages)

Source: Dissertation Abstracts International, Volume: 78-06(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2016.

Includes bibliographical references

Optogenetic functional magnetic resonance imaging (ofMRI) is a novel technique that enables whole-brain visualization of the downstream effects of manipulating a specific neural population. This thesis presents two studies that demonstrate the advantages of ofMRI in brain circuit analysis and offer practical recommendations for ofMRI data analysis. We first describe a study where the technical advantage of ofMRI is utilized in the investigation of arousal networks. The role of central thalamus in forebrain arousal and the frequency-selective modulation of whole-brain networks are uncovered. We then address the challenges of accurate detection and characterization of hemodynamic responses with highly variable temporal dynamics in the ofMRI datasets. In order to find the optimal analysis method, a comprehensive evaluation of the commonly used approaches is presented.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369430219Subjects--Topical Terms:

593561
Neurosciences.
Index Terms--Genre/Form:

554714
Electronic books.

Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies.
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245 1 0 $a Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies.
264 0 $c 2016
300 $a 1 online resource (145 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertation Abstracts International, Volume: 78-06(E), Section: B.
500 $a Advisers: Tom Otis; Jin Hyung Lee.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2016.
504 $a Includes bibliographical references
520 $a Optogenetic functional magnetic resonance imaging (ofMRI) is a novel technique that enables whole-brain visualization of the downstream effects of manipulating a specific neural population. This thesis presents two studies that demonstrate the advantages of ofMRI in brain circuit analysis and offer practical recommendations for ofMRI data analysis. We first describe a study where the technical advantage of ofMRI is utilized in the investigation of arousal networks. The role of central thalamus in forebrain arousal and the frequency-selective modulation of whole-brain networks are uncovered. We then address the challenges of accurate detection and characterization of hemodynamic responses with highly variable temporal dynamics in the ofMRI datasets. In order to find the optimal analysis method, a comprehensive evaluation of the commonly used approaches is presented.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Neurosciences. $3 593561
655 7 $a Electronic books. $2 local $3 554714
690 $a 0317
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of California, Los Angeles. $b Neuroscience. $3 1186597
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10246039 $z click for full text (PQDT)

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