國立虎尾科技大學 |

Signals related to decision-making and uncertainty in the primate prefrontal cortex.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Signals related to decision-making and uncertainty in the primate prefrontal cortex./
Author:	Donahue, Christopher H.
Description:	1 online resource (136 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9781321050714

Signals related to decision-making and uncertainty in the primate prefrontal cortex.
Donahue, Christopher H.

Signals related to decision-making and uncertainty in the primate prefrontal cortex. - 1 online resource (136 pages)

Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.

Thesis (Ph.D.)--Yale University, 2014.

Includes bibliographical references

In this thesis, I describe results from three different experiments that together provide insight into how different cortical regions encode information related to decision making and uncertainty. In the first experiment, I investigate the role of cortical signals in a set of tasks designed to study the exploration/exploitation dilemma, a classic problem that animals face when making decisions under uncertainty. I analyzed single-cell data from awake, behaving monkeys in four different cortical regions: the supplementary eye field (SEF), the dorsolateral prefrontal cortex (DLPFC), the lateral intraparietal area (LIP), and the anterior cingulate cortex (ACC). I find evidence that only the SEF plays a unique role in exploration. In the second set of experiments, I turned my focus to how signals for decision-making are integrated in the DLPFC through the use of a novel probabilistic reversal task. In this task, animals had to track reward probabilities in a task-relevant color dimension while ignoring events related to a task-irrelevant spatial dimension. I describe properties in single neurons that are related to how the DLPFC selects relevant information while filtering out irrelevant information. In the final set of experiments, I used a modified version of the reversal task and studied how neurons in DLPFC, ACC, and orbitofrontal cortex (OFC) integrate information when environmental uncertainty is systematically manipulated. Consistent with theoretical predictions, I find that the animals integrate information from their prior experience to a greater degree when uncertainty is high. Together, these three experiments shed light on how single neurons in cortex may process information about uncertainty to ultimately help animals make decisions that maximize reward.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781321050714Subjects--Topical Terms:

593561
Neurosciences.
Index Terms--Genre/Form:

554714
Electronic books.

Signals related to decision-making and uncertainty in the primate prefrontal cortex.
LDR:02889ntm a2200301K 4500 001 913710
005 20180622095236.5
006 m o u
007 cr mn||||a|a||
008 190606s2014 xx obm 000 0 eng d
020 $a 9781321050714
035 $a (MiAaPQ)AAI3580667
035 $a AAI3580667
040 $a MiAaPQ $b eng $c MiAaPQ
100 1 $a Donahue, Christopher H. $3 1186659
245 1 0 $a Signals related to decision-making and uncertainty in the primate prefrontal cortex.
264 0 $c 2014
300 $a 1 online resource (136 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.
500 $a Adviser: Daeyeol Lee.
502 $a Thesis (Ph.D.)--Yale University, 2014.
504 $a Includes bibliographical references
520 $a In this thesis, I describe results from three different experiments that together provide insight into how different cortical regions encode information related to decision making and uncertainty. In the first experiment, I investigate the role of cortical signals in a set of tasks designed to study the exploration/exploitation dilemma, a classic problem that animals face when making decisions under uncertainty. I analyzed single-cell data from awake, behaving monkeys in four different cortical regions: the supplementary eye field (SEF), the dorsolateral prefrontal cortex (DLPFC), the lateral intraparietal area (LIP), and the anterior cingulate cortex (ACC). I find evidence that only the SEF plays a unique role in exploration. In the second set of experiments, I turned my focus to how signals for decision-making are integrated in the DLPFC through the use of a novel probabilistic reversal task. In this task, animals had to track reward probabilities in a task-relevant color dimension while ignoring events related to a task-irrelevant spatial dimension. I describe properties in single neurons that are related to how the DLPFC selects relevant information while filtering out irrelevant information. In the final set of experiments, I used a modified version of the reversal task and studied how neurons in DLPFC, ACC, and orbitofrontal cortex (OFC) integrate information when environmental uncertainty is systematically manipulated. Consistent with theoretical predictions, I find that the animals integrate information from their prior experience to a greater degree when uncertainty is high. Together, these three experiments shed light on how single neurons in cortex may process information about uncertainty to ultimately help animals make decisions that maximize reward.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Neurosciences. $3 593561
655 7 $a Electronic books. $2 local $3 554714
690 $a 0317
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Yale University. $3 1178968
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3580667 $z click for full text (PQDT)