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Integration of Stable Droplet Formation on a CD Microfluidic Device for Extreme Point of Care Applications.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Integration of Stable Droplet Formation on a CD Microfluidic Device for Extreme Point of Care Applications./
Author:	Ganesh, Shruthi Vatsyayani.
Description:	1 online resource (67 pages)
Notes:	Source: Masters Abstracts International, Volume: 56-05.
Subject:	Engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9780355065930

Integration of Stable Droplet Formation on a CD Microfluidic Device for Extreme Point of Care Applications.
Ganesh, Shruthi Vatsyayani.

Integration of Stable Droplet Formation on a CD Microfluidic Device for Extreme Point of Care Applications. - 1 online resource (67 pages)

Source: Masters Abstracts International, Volume: 56-05.

Thesis (M.S.)--University of California, Irvine, 2017.

Includes bibliographical references

With the advent of microfluidic technologies for molecular diagnostics, a lot of emphasis has been placed on developing diagnostic tools for resource poor regions in the form of Extreme Point of Care devices. To ensure commercial viability of such a device there is a need to develop an accurate sample to answer system, which is robust, portable, isolated yet highly sensitive and cost effective. This need has been a driving force for research involving integration of different microsystems like droplet microfluidics, Compact-disc (CD)microfluidics along with sample preparation and detection modules on a single platform. This work attempts to develop a proof of concept prototype of one such device using existing CD microfluidics tools to generate stable droplets used in point of care diagnostics (POC diagnostics). Apart from using a fairly newer technique for droplet generation and stabilization, the work aims to develop this method focused towards diagnostics for rural healthcare.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355065930Subjects--Topical Terms:

561152
Engineering.
Index Terms--Genre/Form:

554714
Electronic books.

Integration of Stable Droplet Formation on a CD Microfluidic Device for Extreme Point of Care Applications.
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245 1 0 $a Integration of Stable Droplet Formation on a CD Microfluidic Device for Extreme Point of Care Applications.
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300 $a 1 online resource (67 pages)
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500 $a Source: Masters Abstracts International, Volume: 56-05.
500 $a Adviser: Marc Madou.
502 $a Thesis (M.S.)--University of California, Irvine, 2017.
504 $a Includes bibliographical references
520 $a With the advent of microfluidic technologies for molecular diagnostics, a lot of emphasis has been placed on developing diagnostic tools for resource poor regions in the form of Extreme Point of Care devices. To ensure commercial viability of such a device there is a need to develop an accurate sample to answer system, which is robust, portable, isolated yet highly sensitive and cost effective. This need has been a driving force for research involving integration of different microsystems like droplet microfluidics, Compact-disc (CD)microfluidics along with sample preparation and detection modules on a single platform. This work attempts to develop a proof of concept prototype of one such device using existing CD microfluidics tools to generate stable droplets used in point of care diagnostics (POC diagnostics). Apart from using a fairly newer technique for droplet generation and stabilization, the work aims to develop this method focused towards diagnostics for rural healthcare.
520 $a The motivation for this work is first described with an emphasis on the current need for diagnostic testing in rural health-care and the general guidelines prescribed by WHO for such a sample to answer system. Furthermore, a background on CD and droplet microfluidics is presented to understand the merits and de-merits of each system and the need for integrating the two. This phase of the thesis also includes different methods employed/demonstrated to generate droplets on a spinning platform. An overview on the detection platforms is also presented to understand the challenges involved in building an extreme point of care device.
520 $a In the third phase of the thesis, general manufacturing techniques and materials used to accomplish this work is presented. Lastly, design trials for droplet generation is presented. The shortcomings of these trials are solved by investigating mechanisms pertaining to design modification and use of agarose based droplet generation to ensure a more robust sample processing method. This method is further characterized and compared with non-agarose based system and the results are analyzed. In conclusion, future prospects of this work are discussed in relation to extreme POC applications.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Engineering. $3 561152
650 4 $a Materials science. $3 557839
650 4 $a Biomedical engineering. $3 588770
655 7 $a Electronic books. $2 local $3 554714
690 $a 0537
690 $a 0794
690 $a 0541
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of California, Irvine. $b Engineering. $3 1187185
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10261263 $z click for full text (PQDT)