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Utilizing Electrochemical Bioreactors for Efficient Chemical and Biological Applications.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Utilizing Electrochemical Bioreactors for Efficient Chemical and Biological Applications./
Author:	Morrison, Clifford Steven.
Description:	1 online resource (112 pages)
Notes:	Source: Masters Abstracts International, Volume: 56-05.
Subject:	Chemical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9780355079548

Utilizing Electrochemical Bioreactors for Efficient Chemical and Biological Applications.
Morrison, Clifford Steven.

Utilizing Electrochemical Bioreactors for Efficient Chemical and Biological Applications. - 1 online resource (112 pages)

Source: Masters Abstracts International, Volume: 56-05.

Thesis (M.S.)--Rensselaer Polytechnic Institute, 2017.

Includes bibliographical references

Industrial enzymatic reactions that require 1,4-NAD(P)H2 to perform redox transformations often require convoluted coupled enzyme regeneration systems to regenerate 1,4-NAD(P)H2 from NAD(P) and recycle the cofactor for as many turnovers as possible. Renewed interest in recycling the cofactor via electrochemical means is motivated by the low cost of performing electrochemical reactions, easy monitoring of the reaction progress, and straightforward product recovery. However, direct electrochemical cofactor regeneration methods invariably produce adventitious reduced cofactor side products which result in unproductive loss of input NAD(P). I will explore various strategies for mitigating adventitious product formation by electrochemical cofactor regeneration systems and offer insight as to how a successful electrochemical bioreactor system could be designed to engineer efficient 1,4-NAD(P)H2-dependent enzyme reactions of interest to the industrial biocatalysis community. Further, I will explore the utility of an electrochemical bioreactor for delivering external reducing equivalents to an engineered strain of bacteria for improving carbon efficiency and product yield compared to cells that have not been provided external reducing equivalents.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355079548Subjects--Topical Terms:

555952
Chemical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

Utilizing Electrochemical Bioreactors for Efficient Chemical and Biological Applications.
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245 1 0 $a Utilizing Electrochemical Bioreactors for Efficient Chemical and Biological Applications.
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300 $a 1 online resource (112 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Masters Abstracts International, Volume: 56-05.
500 $a Adviser: Mattheos Koffas.
502 $a Thesis (M.S.)--Rensselaer Polytechnic Institute, 2017.
504 $a Includes bibliographical references
520 $a Industrial enzymatic reactions that require 1,4-NAD(P)H2 to perform redox transformations often require convoluted coupled enzyme regeneration systems to regenerate 1,4-NAD(P)H2 from NAD(P) and recycle the cofactor for as many turnovers as possible. Renewed interest in recycling the cofactor via electrochemical means is motivated by the low cost of performing electrochemical reactions, easy monitoring of the reaction progress, and straightforward product recovery. However, direct electrochemical cofactor regeneration methods invariably produce adventitious reduced cofactor side products which result in unproductive loss of input NAD(P). I will explore various strategies for mitigating adventitious product formation by electrochemical cofactor regeneration systems and offer insight as to how a successful electrochemical bioreactor system could be designed to engineer efficient 1,4-NAD(P)H2-dependent enzyme reactions of interest to the industrial biocatalysis community. Further, I will explore the utility of an electrochemical bioreactor for delivering external reducing equivalents to an engineered strain of bacteria for improving carbon efficiency and product yield compared to cells that have not been provided external reducing equivalents.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Chemical engineering. $3 555952
655 7 $a Electronic books. $2 local $3 554714
690 $a 0542
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Rensselaer Polytechnic Institute. $b Chemical Engineering. $3 1148535
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10284525 $z click for full text (PQDT)