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Machine Learning Methods for Diagnosis, Prognosis and Prediction of Long-term Treatment Outcome of Major Depression.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Machine Learning Methods for Diagnosis, Prognosis and Prediction of Long-term Treatment Outcome of Major Depression./
Author:	Nie, Zhi.
Description:	1 online resource (133 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
Subject:	Computer science. -
Online resource:	click for full text (PQDT)
ISBN:	9781369709971

Machine Learning Methods for Diagnosis, Prognosis and Prediction of Long-term Treatment Outcome of Major Depression.
Nie, Zhi.

Machine Learning Methods for Diagnosis, Prognosis and Prediction of Long-term Treatment Outcome of Major Depression. - 1 online resource (133 pages)

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (Ph.D.)--Arizona State University, 2017.

Includes bibliographical references

Major Depression, clinically called Major Depressive Disorder, is a mood disorder that affects about one eighth of population in US and is projected to be the second leading cause of disability in the world by the year 2020. Recent advances in biotechnology have enabled us to collect a great variety of data which could potentially offer us a deeper understanding of the disorder as well as advancing personalized medicine.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369709971Subjects--Topical Terms:

573171
Computer science.
Index Terms--Genre/Form:

554714
Electronic books.

Machine Learning Methods for Diagnosis, Prognosis and Prediction of Long-term Treatment Outcome of Major Depression.
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245 1 0 $a Machine Learning Methods for Diagnosis, Prognosis and Prediction of Long-term Treatment Outcome of Major Depression.
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500 $a Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
500 $a Advisers: Jieping Ye; Jingrui He.
502 $a Thesis (Ph.D.)--Arizona State University, 2017.
504 $a Includes bibliographical references
520 $a Major Depression, clinically called Major Depressive Disorder, is a mood disorder that affects about one eighth of population in US and is projected to be the second leading cause of disability in the world by the year 2020. Recent advances in biotechnology have enabled us to collect a great variety of data which could potentially offer us a deeper understanding of the disorder as well as advancing personalized medicine.
520 $a This dissertation focuses on developing methods for three different aspects of predictive analytics related to the disorder: automatic diagnosis, prognosis, and prediction of long-term treatment outcome. The data used for each task have their specific characteristics and demonstrate unique problems. Automatic diagnosis of melancholic depression is made on the basis of metabolic profiles and micro-array gene expression profiles where the presence of missing values and strong empirical correlation between the variables is not unusual. To deal with these problems, a method of generating a representative set of features is proposed. Prognosis is made on data collected from rating scales and questionnaires which consist mainly of categorical and ordinal variables and thus favor decision tree based predictive models. Decision tree models are known for the notorious problem of overfitting. A decision tree pruning method that overcomes the shortcomings of a greedy nature and reliance on heuristics inherent in traditional decision tree pruning approaches is proposed. The method is further extended to prune Gradient Boosting Decision Tree and tested on the task of prognosis of treatment outcome. Follow-up studies evaluating the long-term effect of the treatments on patients usually measure patients' depressive symptom severity monthly, resulting in the actual time of relapse upper bounded by the observed time of relapse. To resolve such uncertainty in response, a general loss function where the hypothesis could take different forms is proposed to predict the risk of relapse in situations where only an interval for time of relapse can be derived from the observed data.
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538 $a Mode of access: World Wide Web
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650 4 $a Artificial intelligence. $3 559380
650 4 $a Bioinformatics. $3 583857
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710 2 $a Arizona State University. $b Computer Science. $3 845377
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