國立虎尾科技大學 |

Biological mechanisms of minimal residual disease and systemic cancer

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Biological mechanisms of minimal residual disease and systemic cancer/ edited by Julio A. Aguirre-Ghiso.
other author:	Aguirre-Ghiso, Julio A.
Published:	Cham :Springer International Publishing : : 2018.,
Description:	ix, 162 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Cancer - Molecular aspects. -
Online resource:	https://doi.org/10.1007/978-3-319-97746-1
ISBN:	9783319977461

Biological mechanisms of minimal residual disease and systemic cancer
Biological mechanisms of minimal residual disease and systemic cancer[electronic resource] /edited by Julio A. Aguirre-Ghiso. - Cham :Springer International Publishing :2018. - ix, 162 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v.11000065-2598 ;. - Advances in experimental medicine and biology ;780..

Preface -- Foreword. Understanding and targeting minimal residual disease: a path to change cancer patient outcomes -- Epigenetics and Pluripotency Aspects of Disseminated Cancer Cells during Minimal Residual Disease -- Anti-angiogenic therapy-mediated endothelial damage: A driver of breast cancer recurrence?- Minimal Residual Disease in Prostate Cancer -- Minimal Residual Disease in Head and Neck Cancer and Esophageal Cancer -- Detection of Minimal Residual Disease and its Clinical Applications in Melanoma and Breast Cancer Patients Selena -- Preservation of Quiescent Chronic Myelogenous Leukemia Stem Cells by the Bone Marrow Microenvironment -- Minimal Residual Disease in Acute Myeloid leukemia -- Characteristics and therapeutic targeting of minimal residual disease in childhood acute lymphoblastic leukemia -- Minimal Residual Disease in Multiple Myeloma: Impact on response assessment, prognosis and tumor heterogeneity -- Index.

This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.

ISBN: 9783319977461

Standard No.: 10.1007/978-3-319-97746-1doiSubjects--Topical Terms:

668357
Cancer
--Molecular aspects.

LC Class. No.: RC268.4 / .B565 2018

Dewey Class. No.: 616.994

Biological mechanisms of minimal residual disease and systemic cancer
LDR:03752nam a2200337 a 4500 001 930015
003 DE-He213
005 20190424102027.0
006 m d
007 cr nn 008maaau
008 190627s2018 gw s 0 eng d
020 $a 9783319977461 $q (electronic bk.)
020 $a 9783319977454 $q (paper)
024 7 $a 10.1007/978-3-319-97746-1 $2 doi
035 $a 978-3-319-97746-1
040 $a GP $c GP $e rda
041 0 $a eng
050 4 $a RC268.4 $b .B565 2018
072 7 $a MJCL $2 bicssc
072 7 $a MED062000 $2 bisacsh
072 7 $a MJCL $2 thema
082 0 4 $a 616.994 $2 23
090 $a RC268.4 $b .B615 2018
245 0 0 $a Biological mechanisms of minimal residual disease and systemic cancer $h [electronic resource] / $c edited by Julio A. Aguirre-Ghiso.
260 $a Cham : $c 2018. $b Springer International Publishing : $b Imprint: Springer,
300 $a ix, 162 p. : $b ill., digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v v.1100
505 0 $a Preface -- Foreword. Understanding and targeting minimal residual disease: a path to change cancer patient outcomes -- Epigenetics and Pluripotency Aspects of Disseminated Cancer Cells during Minimal Residual Disease -- Anti-angiogenic therapy-mediated endothelial damage: A driver of breast cancer recurrence?- Minimal Residual Disease in Prostate Cancer -- Minimal Residual Disease in Head and Neck Cancer and Esophageal Cancer -- Detection of Minimal Residual Disease and its Clinical Applications in Melanoma and Breast Cancer Patients Selena -- Preservation of Quiescent Chronic Myelogenous Leukemia Stem Cells by the Bone Marrow Microenvironment -- Minimal Residual Disease in Acute Myeloid leukemia -- Characteristics and therapeutic targeting of minimal residual disease in childhood acute lymphoblastic leukemia -- Minimal Residual Disease in Multiple Myeloma: Impact on response assessment, prognosis and tumor heterogeneity -- Index.
520 $a This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.
650 0 $a Cancer $x Molecular aspects. $3 668357
650 1 4 $a Cancer Research. $3 668358
650 2 4 $a Human Genetics. $3 593893
650 2 4 $a Molecular Medicine. $3 668353
650 2 4 $a Cell Biology. $3 593889
650 2 4 $a Drug Resistance. $3 782695
700 1 $a Aguirre-Ghiso, Julio A. $3 1210948
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Advances in experimental medicine and biology ; $v 780. $3 881230
856 4 0 $u https://doi.org/10.1007/978-3-319-97746-1
950 $a Biomedical and Life Sciences (Springer-11642)