國立虎尾科技大學 |

Cancer stem cell resistance to targeted therapy

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Cancer stem cell resistance to targeted therapy/ edited by Cristina Maccalli, Matilde Todaro, Soldano Ferrone.
other author:	Maccalli, Cristina.
Published:	Cham :Springer International Publishing : : 2019.,
Description:	xix, 256 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Drug resistance in cancer cells. -
Online resource:	https://doi.org/10.1007/978-3-030-16624-3
ISBN:	9783030166243

Cancer stem cell resistance to targeted therapy
Cancer stem cell resistance to targeted therapy[electronic resource] /edited by Cristina Maccalli, Matilde Todaro, Soldano Ferrone. - Cham :Springer International Publishing :2019. - xix, 256 p. :ill., digital ;24 cm. - Resistance to targeted anti-cancer therapeutics,v.192196-5501 ;. - Resistance to targeted anti-cancer therapeutics ;v.4..

Cancer Stem Cells: from birth to death -- A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies -- Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies -- Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1 -- Cancer Stem Cell Challenges in Melanoma Characterization and Treatment -- Harnessing the immune system to target cancer cells -- Targeting leukemia stem cells and the immunological bone marrow microenvironment -- Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy -- Cancer stem cells: the players of immune evasion from immunotherapy -- Index.

This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

ISBN: 9783030166243

Standard No.: 10.1007/978-3-030-16624-3doiSubjects--Topical Terms:

681914
Drug resistance in cancer cells.

LC Class. No.: RC271.C5 / C36 2019

Dewey Class. No.: 614.5999

Cancer stem cell resistance to targeted therapy
LDR:03190nam a2200337 a 4500 001 940949
003 DE-He213
005 20190604100716.0
006 m d
007 cr nn 008maaau
008 200417s2019 gw s 0 eng d
020 $a 9783030166243 $q (electronic bk.)
020 $a 9783030166236 $q (paper)
024 7 $a 10.1007/978-3-030-16624-3 $2 doi
035 $a 978-3-030-16624-3
040 $a GP $c GP
041 0 $a eng
050 4 $a RC271.C5 $b C36 2019
072 7 $a MJCL $2 bicssc
072 7 $a MED062000 $2 bisacsh
072 7 $a MJCL $2 thema
082 0 4 $a 614.5999 $2 23
090 $a RC271.C5 $b C215 2019
245 0 0 $a Cancer stem cell resistance to targeted therapy $h [electronic resource] / $c edited by Cristina Maccalli, Matilde Todaro, Soldano Ferrone.
260 $a Cham : $c 2019. $b Springer International Publishing : $b Imprint: Springer,
300 $a xix, 256 p. : $b ill., digital ; $c 24 cm.
490 1 $a Resistance to targeted anti-cancer therapeutics, $x 2196-5501 ; $v v.19
505 0 $a Cancer Stem Cells: from birth to death -- A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies -- Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies -- Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1 -- Cancer Stem Cell Challenges in Melanoma Characterization and Treatment -- Harnessing the immune system to target cancer cells -- Targeting leukemia stem cells and the immunological bone marrow microenvironment -- Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy -- Cancer stem cells: the players of immune evasion from immunotherapy -- Index.
520 $a This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
650 0 $a Drug resistance in cancer cells. $3 681914
650 0 $a Oncology. $3 593951
650 0 $a Immunology. $3 592892
650 0 $a Medicine. $3 644133
650 1 4 $a Cancer Research. $3 668358
650 2 4 $a Molecular Medicine. $3 668353
700 1 $a Maccalli, Cristina. $3 1227929
700 1 $a Todaro, Matilde. $3 1227930
700 1 $a Ferrone, Soldano. $3 1227931
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Resistance to targeted anti-cancer therapeutics ; $v v.4. $3 1063064
856 4 0 $u https://doi.org/10.1007/978-3-030-16624-3
950 $a Biomedical and Life Sciences (Springer-11642)