國立虎尾科技大學 |

Incorporation of heterocycles into combinatorial chemistry

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Incorporation of heterocycles into combinatorial chemistry/ by Eugene V. Babaev.
Author:	Babaev, Eugene V.
Published:	Cham :Springer International Publishing : : 2017.,
Description:	xi, 117 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Heterocyclic chemistry. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-50015-7
ISBN:	9783319500157

Incorporation of heterocycles into combinatorial chemistry
Babaev, Eugene V.

Incorporation of heterocycles into combinatorial chemistry[electronic resource] /by Eugene V. Babaev. - Cham :Springer International Publishing :2017. - xi, 117 p. :ill., digital ;24 cm. - SpringerBriefs in molecular science,2191-5407. - SpringerBriefs in molecular science..

Introduction -- Peptide Synthesis of Libraries of Non-Natural Amino Acids -- The choice of tools for implementing multi-stage transformations. SPOS for Beginners -- Secrets of Parallel Liquid-Phase Synthesis -- Most Combinatorial LPOS Reactions: Reductive Amination with a Scavenger -- A Parallel Ugi Reaction -- Combinatorial Heterocyclic Chemistry in Higher School.

The author has summarized a decade of teaching combinatorial chemistry into this timely brief. The solid phase synthesis of unnatural heterocyclic alpha-amino acids is illustrated by practical examples starting from the ABCs of peptide synthesis explored in chapter one. Chapter two is concerned with the solid phase synthesis which is shown on various techniques - BillBoard, tea-bag, and Lantern devices, and demonstrated on heterocyclic examples and protocols. In the third chapter the tools for accelerating chemical synthesis - solid phase and liquid phase - are reviewed. Here the techniques of parallel refluxing (including microwave and flow technique) and parallel separation (filtration, centrifugation, evaporation, and chromatography) are described. In the chapters 4 and 5 the author goes on to describe how the liquid phase synthesis of heterocycles (reductive amination and Ugi reaction of heterocycles) is illustrated with the use of semi-automated protocols. Finally, the design of combinatorial libraries of heterocycles is reviewed including the original author's findings.

ISBN: 9783319500157

Standard No.: 10.1007/978-3-319-50015-7doiSubjects--Topical Terms:

679848
Heterocyclic chemistry.

LC Class. No.: QD400

Dewey Class. No.: 547.59

Incorporation of heterocycles into combinatorial chemistry
LDR:02464nam a2200325 a 4500 001 957693
003 DE-He213
005 20161203121324.0
006 m d
007 cr nn 008maaau
008 201118s2017 gw s 0 eng d
020 $a 9783319500157 $q (electronic bk.)
020 $a 9783319500133 $q (paper)
024 7 $a 10.1007/978-3-319-50015-7 $2 doi
035 $a 978-3-319-50015-7
040 $a GP $c GP
041 0 $a eng
050 4 $a QD400
072 7 $a PNN $2 bicssc
072 7 $a SCI013040 $2 bisacsh
082 0 4 $a 547.59 $2 23
090 $a QD400 $b .B112 2017
100 1 $a Babaev, Eugene V. $3 1249454
245 1 0 $a Incorporation of heterocycles into combinatorial chemistry $h [electronic resource] / $c by Eugene V. Babaev.
260 $a Cham : $c 2017. $b Springer International Publishing : $b Imprint: Springer,
300 $a xi, 117 p. : $b ill., digital ; $c 24 cm.
490 1 $a SpringerBriefs in molecular science, $x 2191-5407
505 0 $a Introduction -- Peptide Synthesis of Libraries of Non-Natural Amino Acids -- The choice of tools for implementing multi-stage transformations. SPOS for Beginners -- Secrets of Parallel Liquid-Phase Synthesis -- Most Combinatorial LPOS Reactions: Reductive Amination with a Scavenger -- A Parallel Ugi Reaction -- Combinatorial Heterocyclic Chemistry in Higher School.
520 $a The author has summarized a decade of teaching combinatorial chemistry into this timely brief. The solid phase synthesis of unnatural heterocyclic alpha-amino acids is illustrated by practical examples starting from the ABCs of peptide synthesis explored in chapter one. Chapter two is concerned with the solid phase synthesis which is shown on various techniques - BillBoard, tea-bag, and Lantern devices, and demonstrated on heterocyclic examples and protocols. In the third chapter the tools for accelerating chemical synthesis - solid phase and liquid phase - are reviewed. Here the techniques of parallel refluxing (including microwave and flow technique) and parallel separation (filtration, centrifugation, evaporation, and chromatography) are described. In the chapters 4 and 5 the author goes on to describe how the liquid phase synthesis of heterocycles (reductive amination and Ugi reaction of heterocycles) is illustrated with the use of semi-automated protocols. Finally, the design of combinatorial libraries of heterocycles is reviewed including the original author's findings.
650 0 $a Heterocyclic chemistry. $3 679848
650 0 $a Combinatorial chemistry. $3 562690
650 1 4 $a Chemistry. $3 593913
650 2 4 $a Organic Chemistry. $3 673440
650 2 4 $a Pharmaceutical Sciences/Technology. $3 768561
650 2 4 $a Science Education. $3 668800
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a SpringerBriefs in molecular science. $3 883495
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-50015-7
950 $a Chemistry and Materials Science (Springer-11644)