國立虎尾科技大學 |

Neurodegenerative Disorders as Systemic Diseases

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Neurodegenerative Disorders as Systemic Diseases/ edited by Keiji Wada.
other author:	Wada, Keiji.
Description:	VIII, 304 p. 34 illus., 19 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Neurosciences. -
Online resource:	https://doi.org/10.1007/978-4-431-54541-5
ISBN:	9784431545415

Neurodegenerative Disorders as Systemic Diseases
Neurodegenerative Disorders as Systemic Diseases[electronic resource] /edited by Keiji Wada. - 1st ed. 2015. - VIII, 304 p. 34 illus., 19 illus. in color.online resource.

PART I A NEW CONCEPT OF NEURODEGENERATION IN BIOLOGY AND PATHOPHYSIOLOGY -- 1 Conformational disease and RNA disease theory in the context of neurodegenerative diseases -- 2 Brain-peripheral organ communication -- 3 The brain-immune network in spinal cord injury -- PART II CHANGES IN CLINICAL EVALUATION AND NEW BIOMARKERS -- 4 Renovation of clinical evaluation and new biomarkers -- 5 Clinical Systems Neuroscience -- PART III RISK FACTORS IN NEURODEGENERATION -- 6 Genetic risk factors for neurodegenerative diseases -- 7 Intermediate phenotypes approach for neuropsychiatric disorders -- PART IV FUTURE DIRECTIONS FOR THERAPY -- 8 Significance of mechanism-oriented research toward neuronal protection therapy against neurodegenerative disorders ~ ZNRF1 E3 ubiquitin ligase as a critical mediator for Wallerian degeneration and neuronal apoptosis -- 9 Drug development for neurodegenerative diseases -- 10 Physical therapy and rehabilitation in patients with degenerative cerebellar diseases: current evidence and future direction -- 11 Home- and Community-based medical care for neurodegenerative diseases -ALS as an illustration- -- PART V HEALTH PROMOTION: PREVENTION AND QUALITY OF LIFE -- 12 Information Environment and Brain Function: A New Concept of the Environment for the Brain -- 13 Social Implementation of Neurodegenerative Disease Research and Neuroethics.-.

This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.

ISBN: 9784431545415

Standard No.: 10.1007/978-4-431-54541-5doiSubjects--Topical Terms:

593561
Neurosciences.

LC Class. No.: RC321-580

Dewey Class. No.: 612.8

Neurodegenerative Disorders as Systemic Diseases
LDR:03882nam a22003975i 4500 001 965254
003 DE-He213
005 20200706040041.0
007 cr nn 008mamaa
008 201211s2015 ja | s |||| 0|eng d
020 $a 9784431545415 $9 978-4-431-54541-5
024 7 $a 10.1007/978-4-431-54541-5 $2 doi
035 $a 978-4-431-54541-5
050 4 $a RC321-580
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
072 7 $a PSAN $2 thema
082 0 4 $a 612.8 $2 23
245 1 0 $a Neurodegenerative Disorders as Systemic Diseases $h [electronic resource] / $c edited by Keiji Wada.
250 $a 1st ed. 2015.
264 1 $a Tokyo : $b Springer Japan : $b Imprint: Springer, $c 2015.
300 $a VIII, 304 p. 34 illus., 19 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a PART I A NEW CONCEPT OF NEURODEGENERATION IN BIOLOGY AND PATHOPHYSIOLOGY -- 1 Conformational disease and RNA disease theory in the context of neurodegenerative diseases -- 2 Brain-peripheral organ communication -- 3 The brain-immune network in spinal cord injury -- PART II CHANGES IN CLINICAL EVALUATION AND NEW BIOMARKERS -- 4 Renovation of clinical evaluation and new biomarkers -- 5 Clinical Systems Neuroscience -- PART III RISK FACTORS IN NEURODEGENERATION -- 6 Genetic risk factors for neurodegenerative diseases -- 7 Intermediate phenotypes approach for neuropsychiatric disorders -- PART IV FUTURE DIRECTIONS FOR THERAPY -- 8 Significance of mechanism-oriented research toward neuronal protection therapy against neurodegenerative disorders ~ ZNRF1 E3 ubiquitin ligase as a critical mediator for Wallerian degeneration and neuronal apoptosis -- 9 Drug development for neurodegenerative diseases -- 10 Physical therapy and rehabilitation in patients with degenerative cerebellar diseases: current evidence and future direction -- 11 Home- and Community-based medical care for neurodegenerative diseases -ALS as an illustration- -- PART V HEALTH PROMOTION: PREVENTION AND QUALITY OF LIFE -- 12 Information Environment and Brain Function: A New Concept of the Environment for the Brain -- 13 Social Implementation of Neurodegenerative Disease Research and Neuroethics.-.
520 $a This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.
650 0 $a Neurosciences. $3 593561
650 0 $a Neurology . $3 1253459
650 0 $a Psychiatry. $3 585488
650 0 $a Neurobiology. $3 573189
650 2 4 $a Neurology. $3 593894
700 1 $a Wada, Keiji. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1068980
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9784431545408
776 0 8 $i Printed edition: $z 9784431545422
776 0 8 $i Printed edition: $z 9784431562986
856 4 0 $u https://doi.org/10.1007/978-4-431-54541-5
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)