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Does Late-in-Life Aerobic Exercise Training Alter the Relative Abundance of the Murine Intestinal Microbiota?

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Does Late-in-Life Aerobic Exercise Training Alter the Relative Abundance of the Murine Intestinal Microbiota?/
作者:	Hansen, Michele.
面頁冊數:	1 online resource (83 pages)
附註:	Source: Masters Abstracts International, Volume: 84-07.
Contained By:	Masters Abstracts International84-07.
標題:	Physiology. -
電子資源:	click for full text (PQDT)
ISBN:	9798368453675

Does Late-in-Life Aerobic Exercise Training Alter the Relative Abundance of the Murine Intestinal Microbiota?
Hansen, Michele.

Does Late-in-Life Aerobic Exercise Training Alter the Relative Abundance of the Murine Intestinal Microbiota? - 1 online resource (83 pages)

Source: Masters Abstracts International, Volume: 84-07.

Thesis (M.S.)--The University of Utah, 2021.

Includes bibliographical references

Results from clinical and preclinical models indicate that exercise training limits cardiovascular risk. A potential mechanism is that consistent physical activity alters the relative abundance of intestinal microbes to an extent that positively influences risk factors for cardiovascular disease (CVD). The overall hypothesis that late-in-life exercise training re-establishes a beneficial and cooperative intestinal microbiome to an extent that lessens CVD risk has never been evaluated. We tested three hypotheses, i.e., late-in-life exercise training: (i) rejuvenates age-associated declines in the relative abundance of intestinal microbiota; (ii) re-establishes age-associated decrements in myocardial function; and (iii) produces improvements in the relative abundance of intestinal microbiota and myocardial function that are positively correlated. Older (O, 21 months) male C57BL/6J mice completed a 12-week protocol that consisted of no exercise training (SED) or a progressive-resistance treadmill-running protocol (ETR). Adult (A, 4 months) male C57BL/6J mice did not train. Upon completion, 24-month-old O-ETR mice displayed less fat mass, improved exercise capacity, and increased soleus muscle citrate synthase (CS) enzyme activity vs. O-SED animals. O-ETR mice displayed CS activity and exercise capacity levels similar to A mice (all p < 0.05). These findings indicate our training program was efficacious. Regarding the first hypothesis, decreased (p < 0.05) intestinal microbial relative abundance (e.g., Parabacteroides, Rikenella, Paraprevotella, and Dorea) otherwise observed in O-SED vs. A mice was rejuvenated (p < 0.05) in O-ETR vs. O-SED mice. Second, systolic function (e.g., fractional shortening, FS), diastolic function (e.g., early phase of diastolic filing/late phase of diastolic filling, E/A ratio), and overall left-ventricular function, e.g., myocardial performance index, MPI) otherwise impaired (p < 0.05) in O-SED vs. A mice were improved in O-ETR animals (p < 0.05). Third, training-induced improvements in relative abundance of intestinal microbiota (e.g., Parabacteroides, Dorea) and myocardial function (e.g., FS, E/A ratio, MPI) observed in O-ETR mice correlated positively (p < 0.05). Collectively, these results indicate that latein-life exercise training: (i) rejuvenates the relative abundance of intestinal microbiota; (ii) reestablishes myocardial function; and (iii) improves intestinal microbiota to an extent that correlates positively with FS, E/A ratio, and MPI. These results indicate latein-life exercise training-induced a beneficial remodeling of the intestinal microbiota that associates positively with improved cardiac function.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798368453675Subjects--Topical Terms:

673386
Physiology.
Subjects--Index Terms:

Cardiac functionIndex Terms--Genre/Form:

554714
Electronic books.

Does Late-in-Life Aerobic Exercise Training Alter the Relative Abundance of the Murine Intestinal Microbiota?
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