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Precision Nutrition for the Management and Prevention of Chronic Disease : = Exploring the Relationship Between Intestinal Permeability and High-Density Lipoproteins in Alzheimer's Disease.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Precision Nutrition for the Management and Prevention of Chronic Disease :/
Reminder of title:	Exploring the Relationship Between Intestinal Permeability and High-Density Lipoproteins in Alzheimer's Disease.
Author:	Romo, Eduardo.
Description:	1 online resource (90 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
Contained By:	Dissertations Abstracts International85-11B.
Subject:	Nutrition. -
Online resource:	click for full text (PQDT)
ISBN:	9798382606453

Precision Nutrition for the Management and Prevention of Chronic Disease : = Exploring the Relationship Between Intestinal Permeability and High-Density Lipoproteins in Alzheimer's Disease.
Romo, Eduardo.

Precision Nutrition for the Management and Prevention of Chronic Disease :Exploring the Relationship Between Intestinal Permeability and High-Density Lipoproteins in Alzheimer's Disease. - 1 online resource (90 pages)

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

Thesis (Ph.D.)--University of California, Davis, 2024.

Includes bibliographical references

High-density lipoproteins (HDL), inflammation pathways, and associated proteins like lipopolysaccharide binding protein (LBP) play complex and interrelated roles in major age-related diseases including cardiovascular disease and Alzheimer's disease (AD). This dissertation integrates findings across multiple key studies to elucidate novel insights of the "lipoprotein-gastrointestinal-inflammation axis" underlying these conditions. By reviewing evidence on HDL glycoprotein alterations in disease, identifying elevated LBP in Alzheimer's patients and analyzing impacts of fiber supplementation on inflammation in preliminary trials, new insights emerge. These discoveries pave the way for improved risk prediction, prevention, and treatment strategies that leverage knowledge of HDL, LBP, and glycosylation aberrations. This body of work catalyzes future research to enable transformative advances against society's most pressing health burdens.1. Chapter one reviews research on glycosylation of HDL-associated proteins, showing it is altered in diseases like cardiovascular disease (CVD) and has potential as a diagnostic biomarker. It discusses analytical methods for profiling HDL glycoproteins and evidence linking glycosylation to HDL function. The chapter emphasizes the need for large cohort studies on HDL glycan profiles and health outcomes.2. Chapter two presents findings from an Alzheimer's study identifying significantly higher LBP concentrations in plasma fractions of apolipoprotein E (APOE)3E3 AD patients compared to APOE3E4 controls. LBP was associated with dementia severity and verbal memory scores. This implicates LBP-driven inflammation in AD pathogenesis in genetically low-risk individuals.3. Chapter three analyzes data from a prebiotic fiber supplementation trial, finding limited overall impacts of the fiber supplement on plasma concentrations of LBP and HDL function, but reductions in LBP selectively in those individuals with higher baseline LBP. Our findings suggest that some individuals who consume low-fiber diets have increased gut permeability, and for these individuals, even a low-dose daily fiber supplement can improve gut barrier function. Together, these discoveries reveal new aspects of lipoproteins, LBP, and glycosylation in major age-related disease. This dissertation promotes future research leveraging this knowledge for enhanced prediction, prevention, and treatment of conditions like AD and CVD. Key priorities include large glycoprofiling studies, elucidating LBP's role in AD, and assessing early-life precision nutrition anti-inflammatory interventions in at-risk groups.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798382606453Subjects--Topical Terms:

581367
Nutrition.
Subjects--Index Terms:

Alzheimer's diseaseIndex Terms--Genre/Form:

554714
Electronic books.

Precision Nutrition for the Management and Prevention of Chronic Disease : = Exploring the Relationship Between Intestinal Permeability and High-Density Lipoproteins in Alzheimer's Disease.
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520 $a High-density lipoproteins (HDL), inflammation pathways, and associated proteins like lipopolysaccharide binding protein (LBP) play complex and interrelated roles in major age-related diseases including cardiovascular disease and Alzheimer's disease (AD). This dissertation integrates findings across multiple key studies to elucidate novel insights of the "lipoprotein-gastrointestinal-inflammation axis" underlying these conditions. By reviewing evidence on HDL glycoprotein alterations in disease, identifying elevated LBP in Alzheimer's patients and analyzing impacts of fiber supplementation on inflammation in preliminary trials, new insights emerge. These discoveries pave the way for improved risk prediction, prevention, and treatment strategies that leverage knowledge of HDL, LBP, and glycosylation aberrations. This body of work catalyzes future research to enable transformative advances against society's most pressing health burdens.1. Chapter one reviews research on glycosylation of HDL-associated proteins, showing it is altered in diseases like cardiovascular disease (CVD) and has potential as a diagnostic biomarker. It discusses analytical methods for profiling HDL glycoproteins and evidence linking glycosylation to HDL function. The chapter emphasizes the need for large cohort studies on HDL glycan profiles and health outcomes.2. Chapter two presents findings from an Alzheimer's study identifying significantly higher LBP concentrations in plasma fractions of apolipoprotein E (APOE)3E3 AD patients compared to APOE3E4 controls. LBP was associated with dementia severity and verbal memory scores. This implicates LBP-driven inflammation in AD pathogenesis in genetically low-risk individuals.3. Chapter three analyzes data from a prebiotic fiber supplementation trial, finding limited overall impacts of the fiber supplement on plasma concentrations of LBP and HDL function, but reductions in LBP selectively in those individuals with higher baseline LBP. Our findings suggest that some individuals who consume low-fiber diets have increased gut permeability, and for these individuals, even a low-dose daily fiber supplement can improve gut barrier function. Together, these discoveries reveal new aspects of lipoproteins, LBP, and glycosylation in major age-related disease. This dissertation promotes future research leveraging this knowledge for enhanced prediction, prevention, and treatment of conditions like AD and CVD. Key priorities include large glycoprofiling studies, elucidating LBP's role in AD, and assessing early-life precision nutrition anti-inflammatory interventions in at-risk groups.
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